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Phenobarbital has been proven to shorten the 50 %-lifetime of doxycycline for as long as two weeks just after barbiturate therapy is discontinued. This system is probably in the induction of hepatic microsomal enzymes that metabolize the antibiotic.バルビツール酸系の常として、呼吸抑制が強く、麻酔作用を発揮する量と